Frank Austin Nothaft

Technical Director of Healthcare and Life Sciences, Databricks

Frank is the Technical Director for the Healthcare and Life Sciences vertical at Databricks. Prior to joining Databricks, Frank was a lead developer on the Big Data Genomics/ADAM and Toil projects at UC Berkeley, and worked at Broadcom Corporation on design automation techniques for industrial scale wireless communication chips. Frank holds a PhD and Masters of Science in Computer Science from UC Berkeley, and a Bachelor’s of Science with Honors in Electrical Engineering from Stanford University.



Improving Therapeutic Development at Biogen with UK Biobank Data, Databricks, and DNAnexusSummit 2020

Large scale genomics datasets like the UK Biobank are revolutionizing how pharmaceutical companies identify targets for therapeutic development. However, turning petabytes of genomics data into actionable links between genotype and phenotype is out of reach for companies using legacy genomic data technologies. In this talk, Biogen will describe how they collaborated with DNAnexus and Databricks to move their on-premises data infrastructure into the AWS cloud. By combining the DNAnexus platform with the Databricks Genomics Runtime, Biogen was able to use the UK Biobank dataset to identify genes containing protein-truncating variants that impact human longevity and neurological status.

Saving Lives with Unified AnalyticsSummit 2018

Big data and AI are joined at the hip: the best AI applications require massive amounts of constantly updated training data to build state-of-the-art models AI has always been one of the most exciting applications of big data and Apache Spark. Increasingly Spark users want to integrate Spark with distributed deep learning and machine learning frameworks built for state-of-the-art training.

Genomics DemoSummit 2018

Scaling Genomics Pipelines in the CloudSummit 2018

Next generation sequencing is becoming cheaper and more accessible. The volume of data sequenced is increasing faster than Moore’s Law. However, it is still expensive and slow to go from raw reads to variant calls, and to produce annotated variants that can then be analyzed downstream. In this talk, we will discuss the first state of the art, scalable and simple DNA sequencing workflow that is built on top of Apache Spark and the Databricks APIs. The pipeline is simple to set up, is easy to scale out, and can sequence a 30x coverage genome cost efficiently on the cloud. We'll introduce the problem of alignment and variant calling on whole genomes, discuss the challenges of building a simple yet scalable pipeline and demonstrate our solution. This talk should be of interest to developers wishing to build ETL pipelines on top of Apache Spark, as well as biochemists and molecular biologists who wish to learn how to develop cheap and fast DNA sequencing pipelines. Sesson hashtag: #DevSAIS10

ADAM: Fast, Scalable Genomic AnalysisSummit 2014

ADAM is a high-performance distributed processing pipeline and API for DNA sequencing data. To allow computation to scale on clusters with more than a hundred nodes, ADAM uses Apache Spark as a computational engine and stores data using Apache Avro and the open-source Parquet columnar store. This scalability allows us to perform complex, computationally heavy tasks such as base quality score recalibration (BQSR), or duplicate marking on high coverage human genomes (> 60%, 236GB) in under a half hour. In tests on the Amazon Elastic Compute platform, we achieve a 50% speedup over current processing pipelines, and a lower processing cost. To achieve scalability in a distributed setting, we rephrased conventional sequential DNA processing algorithms as data-parallel algorithms. In this talk, we’ll discuss the general principles we used for making these algorithms scalable while achieving full concordance with the equivalent serial algorithms. Additionally, by adapting genomic analysis to a commodity distributed analytics platform like Apache Spark, it is easier to perform ad hoc analysis and machine learning on genomic data. We will discuss how this impacts the clinical use of DNA analysis pipelines, as well as population genomics.

Processing 70Tb Of Genomics Data With ADAM And ToilSummit 2016

Modern genome sequencing projects capture hundreds of gigabytes of data per individual. In this talk, we discuss recent work where we used the Spark-based ADAM tool to recompute genomic variants from 70TB of reads from the Simons Genome Diversity dataset. ADAM presents a drop-in, Spark-based replacement for conventional genomics pipelines like the GATK. We ran this computation across hundreds of nodes on Amazon EC2 using Toil, a novel cluster orchestration tool. Toil was used to automatically scale the number of nodes used, and to seamlessly run large single node jobs and Spark clusters in a single workflow. By combining ADAM and Toil, we are able to improve end-to-end pipeline runtime while taking advantage of the EC2 Spot Instances market. Additionally, Toil is designed for scientific reproducibility, and our entire workflow was run using Docker containers to ensure that there is a static set of binaries that could be used to reproduce the pipeline at a later date. ADAM and Toil are both freely available Apache 2 licensed tools.

Processing Terabyte-Scale Genomics Datasets with ADAMSummit East 2017

The detection and analysis of rare genomic events requires integrative analysis across large cohorts with terabytes to petabytes of genomic data. Contemporary genomic analysis tools have not been designed for this scale of data-intensive computing. This talk presents ADAM, an Apache 2 licensed library built on top of the popular Apache Spark distributed computing framework. ADAM is designed to allow genomic analyses to be seamlessly distributed across large clusters, and presents a clean API for writing parallel genomic analysis algorithms. In this talk, we’ll look at how we’ve used ADAM to achieve a 3.5× improvement in end-to-end variant calling latency and a 66% cost improvement over current toolkits, without sacrificing accuracy. We will talk about a recent recompute effort where we have used ADAM to recall the Simons Genome Diversity Dataset against GRCh38. We will also talk about using ADAM alongside Apache Hbase to interactively explore large variant datasets.